Alexander-Arnold, who was injured and missed last year’s Euros, has only played once for his country so far this year and was not used as a substitute in Friday’s loss to Italy.
James Ward-Prowse, Jarrod Bowen, and Fikayo Tomori are also excluded.
Ivan Toney of Brentford, though, is scheduled to make his international debut.
Toney, who has five goals in the Premier League this season, was called up for the first time by England this month but was left out of the squad for the match against Italy.
The 23-man Three Lions roster for their match against Germany includes him, while Manchester City midfielder Jack Grealish is unavailable due to a ban.
The other exclusions are due to squad decisions rather than injuries.
What is Alexander-Arnold like?
With an average of 2.7 chances created per game this season in all club competitions, Alexander-Arnold leads the list of English full-backs.
The 23-year-old has played 737 minutes, more than any other English full-back, and has two league goals for Liverpool this season.
Despite frequently appearing for AC Milan in Serie A, center-back Tomori was also inactive against Italy.
Instead, manager Gareth Southgate decided to start Harry Maguire, who has only played three times for Manchester United in the Premier League this year.
England plays its last game on Monday at Wembley before Southgate names his team for the 2022 World Cup, which will take place in Qatar from 20 November to 18 December.
England has lost five straight games, and their 1-0 loss in Milan on Friday resulted in their elimination from their Nations League group.
Alexander-exclusion Arnold’s reveals his place in the England right-back hierarchy and probably the manager Gareth Southgate’s thinking.
When England plays a back four, Kyle Walker is the go-to right-back. He is also one of the back three in Southgate’s preferred configuration. It can be claimed that Kieran Trippier is superior to the Liverpool player because of his versatility, while Reece James has also appeared to overtake Alexander-Arnold since he provides both a greater attacking threat and more defensive stability.
There is no denying Alexander-quality Arnold’s or the fact that he is one of England’s top ball-handlers. Although he produces fantastic attacking results for Liverpool, he doesn’t have as much flexibility with England as he does with his club.
Southgate is criticized for being overly conservative, yet his methods have enabled England to reach their first European Championship final and a World Cup semi-final, so he has cause to do so. Additionally, Alexander-injury Arnold’s caused him to miss the Euros, which goes without saying.
Being left out of the last matchday squad before the team departs for the World Cup will be a major setback for him, and it will be felt the more keenly given that he did not make the substitutes’ list in Italy and will leave this camp without participating in a single game.
There is no doubt that Alexander-position Arnold’s in the 26-man Qatari team following this international break is in danger.